Note: Presented at the 3rd National Osteoporosis Congress. Antalya, Turkey,  October 15-19, 2008

Summary

Combining pharmacotherapy with non-pharmacotherapy is fundamental to the successful management of osteopenia and osteoporosis. The choice of pharmacotherapy depends on the patient’s age, bone mineral density and serum biochemical markers of bone.  HRT should not be used for treatment of osteoporosis. As with pharmacotherapy, rehabilitation management is challenging and innovative.  Non-pathologic spontaneous vertebral fractures that occur at the level of the spine are purely osteoporosis-related.  On the other hand, the majority of non-vertebral fractures that are of special clinical significance are fall-related.  Therefore, reducing the risk for fracture through the prevention of falls is as important as increasing bone mass. (From the World of Osteoporosis 2009;15:52-8)
Key words: Osteoporosis, non-pharmacologic therapy, exercises

Özet

Farmakoterapi ile nonfarmakolojik tedavilerin kombine edilmesi osteopeni ve osteoporoz tedavisinin başarısı için esastır. Farmakoterapinin seçimi hastanın yaşı, kemik mineral yoğunluğu ve biokimyasal kemik belirleyicilerine göre yapılır. HRT osteoporoz tedavisi için kullanılmamalıdır. Farmakoterapi gibi, rehabilitasyon uygulamaları da zorluklarla karşılaşabilir ve yeni yaklaşımlar gerekebilir. Omurga düzeyinde oluşan travmatik olmayan spontan vertebra kırıkları osteoporoza bağlıdır. Diğer yandan özel klinik önemi olan vertebra dışı kırıkların çoğunluğu düşme ile ilişkilidir. Bu nedenle düşmeleri önleyerek kırıktan korunmak kemik kütlesini artırmak kadar önemlidir. (Osteoporoz Dünyasından 2009;15:52-8)
Anahtar kelimeler: Osteoporoz, nonfarmakolojik, tedavi, egzersiz

Note: Presented at the 3rd National Osteoporosis Congress. Antalya, Turkey,  October 15-19, 2008

Summary

Combining pharmacotherapy with non-pharmacotherapy is fundamental to the successful management of osteopenia and osteoporosis. The choice of pharmacotherapy depends on the patient’s age, bone mineral density and serum biochemical markers of bone.  HRT should not be used for treatment of osteoporosis. As with pharmacotherapy, rehabilitation management is challenging and innovative.  Non-pathologic spontaneous vertebral fractures that occur at the level of the spine are purely osteoporosis-related.  On the other hand, the majority of non-vertebral fractures that are of special clinical significance are fall-related.  Therefore, reducing the risk for fracture through the prevention of falls is as important as increasing bone mass. (From the World of Osteoporosis 2009;15:52-8)
Key words: Osteoporosis, non-pharmacologic therapy, exercises

Özet

Farmakoterapi ile nonfarmakolojik tedavilerin kombine edilmesi osteopeni ve osteoporoz tedavisinin başarısı için esastır. Farmakoterapinin seçimi hastanın yaşı, kemik mineral yoğunluğu ve biokimyasal kemik belirleyicilerine göre yapılır. HRT osteoporoz tedavisi için kullanılmamalıdır. Farmakoterapi gibi, rehabilitasyon uygulamaları da zorluklarla karşılaşabilir ve yeni yaklaşımlar gerekebilir. Omurga düzeyinde oluşan travmatik olmayan spontan vertebra kırıkları osteoporoza bağlıdır. Diğer yandan özel klinik önemi olan vertebra dışı kırıkların çoğunluğu düşme ile ilişkilidir. Bu nedenle düşmeleri önleyerek kırıktan korunmak kemik kütlesini artırmak kadar önemlidir. (Osteoporoz Dünyasından 2009;15:52-8)
Anahtar kelimeler: Osteoporoz, nonfarmakolojik, tedavi, egzersiz

Combining pharmacotherapy with non-pharmacotherapy is fundamental to the successful management of osteopenia and osteoporosis (1,2). The musculoskeletal and psychological benefits provided by rehabilitation measures are of great importance for improvement of the patient’s quality of life. Musculoskeletal rehabilitation and nonpharmacologic interventions consist of exercise, physical management of pain, proper use of orthotics, and prevention of falls and fractures (1,2). Bone mass is frequently considered to be the most important determinant of fragility, but it explains only less than half of the observed fracture risk at the level of the spine.  Non-pathologic spontaneous vertebral fractures that occur at the level of the spine are purely osteoporosis-related. On the other hand, the majority of non-vertebral fractures that are of special clinical significance are fall-related.  Therefore, reducing the risk for fracture through the prevention of falls is as important as increasing bone mass.  However, the prevention of falls is more challenging than improving bone mass. Falls are multifactorial, and prevention or reduction of falls requires a combination of pharmacologic and nonpharmacologic interventions.  Risk of falls can be extrinsic, i.e. related to environmental factors, or intrinsic, i.e. related to musculoskeletal and neuromuscular health of the individual. Table 1 shows factors that increase risk of falls (3).
In men and women, the combination of age-related sarcopenia and reduction of physical activity can affect musculoskeletal health and contribute to the development of bone fragility and falls  (4). Musculoskeletal-wise, women are more challenged than men since they start adulthood with lower muscle strength (5) and lower bone mass than men. Reduction in the biomechanical competence of the axial skeleton can result in challenging complications (6). Complications of osteoporosis can vary from “silent” compression fractures of vertebral bodies to sacral insufficiency fractures to “breath-taking” fractures of the spine or femoral neck. The exponential loss of axial bone mass at the postmenopausal stage is not accompanied by an incremental loss of muscle strength.  Loss of muscle strength follows a more gradual course and is not affected significantly by a sudden hormonal decline, as is the case with bone loss.  With increasing age, axial loss of muscle strength is more significant in women than appendicular muscle loss (7). This muscle loss may contribute to osteoporosis-related axial disfigurations as well as increased incidence of falls.
Skeletal structures are physically and kinematically acted upon by muscles. Axial and appendicular muscle strength in boys and girls is about the same until age 10 when a disparity begins to develop (5). Muscle strength decreases with age in men and women (Fig 1) (4).     
Kyphosis commonly occurs with reduced back muscle strength, vertebral bone loss or fracture.  Hyperkyphosis results in back pain, decreased vital capacity, and increased risk of further vertebral fractures and unsteadiness of gait (8). In many individuals, it also creates a negative self-image (9). In severe kyphotic posture, pressure of the lower part of the rib cage over the pelvic rim causes significant flank pain, tenderness and compromises breathing (2).   In healthy posture, there is sufficient space between the lower ribs and the iliac crest so that no contact occurs, even on lateral bending of the trunk.  In cases of severe osteoporosis with compression fractures, dorsal kyphosis, loss of height, and iliocostal contact occurs (2).   The latter can result in iliocostal friction syndrome and flank pain.  Fortunately, kyphotic posture and vertebral fractures are no longer disorders about which nothing can be done. Scapular retraction and dynamic back strengthening can decrease thoracic hyperkyphosis at any age  (10). Helping the patient to decrease kyphotic posturing through recruitment of back extensors for provision of better dynamic/static posturing can reduce pain, increase mobility, reduce depression and improve the patient’s quality of life.  The author’s Spinal Proprioceptive Extension Exercise Dynamic (SPEED) program can help to decrease thoracic hyperkyphosis and risk of falls (11). Bracing, unless geared to a posture training type of program, can decrease back extensor strength. (Fig 2 a, b, c, d, e, f, g)  (12). In fact, the use of rigid back supports can result in selective weakness in back extensors, the major supportive muscles of the back (Fig 3). To be helpful, spinal orthotics need to decrease pain and expedite ambulation and mobility. Orthotics that function through increment in intra-abdominal pressure, however, are contraindicated in cases of a) hiatal hernia; b) iliocostal friction syndrome; c) severe kyphosis; d) COPD; and e) significant loss of height (2).  
Osteoporosis remains asymptomatic until fracture occurs.  Back pain is usually the osteoporotic patient’s main complaint.   Vertebral compression fractures often occur in the mid-thoracic and upper lumbar vertebral bodies (Fig 4), followed in order of frequency by low thoracic and lower lumbar vertebral bodies.  The cervical and upper thoracic vertebrae are rarely, if ever, involved (13). Back pain is a major cause of depression and disability in osteoporotic patients (14). Osteoporosis-related back pain is of two types - acute and chronic (Tables 2 and 3).  Management of acute back pain differs from that of chronic back pain.  Proper management of pain related to acute vertebral compression fractures can reduce the risk of developing chronic pain syndrome.  Limited bed rest (1-2 days), non-codeine derivative analgesics, sedative physical therapy and proper bracing are some of the helpful measures. Calcitonin has both antiresorptive and analgesic effect and may be used for a few months (15). Back pain and immobility can decrease with the use of spinal orthoses.  However, continuous use of spinal orthotics can result in truncal muscular weakness and further complicate the musculoskeletal challenges related to osteoporosis (Fig 3) (16). Sacral insufficiency fractures require sedative physical therapy and reduction of weightbearing with use of gait aids and orthoses (17).  One of the major musculoskeletal challenges of osteoporosis is spinal disfiguration such as kyphoscoliosis which results in chronic back pain and also can contribute to falls and further fracture (16,17).
Proper exercise and rehabilitative measures have the potential to build bone mass and decrease the rate of bone loss.  Not all types of physical exercises are osteogenic.  Stronger back extensors have been proven to correlate with reduced kyphosis and a lower number of vertebral fractures (Fig 5) (18). Research studies show that spinal extensor exercises are the preferred choice for strengthening back extensors (Fig 6) (13,19). The author has hypothesized that back exercises performed in a prone position, rather than in a vertical position, may have a greater effect on decreasing risk for vertebral fractures without resulting in compression fracture. One can theorize that the risk for vertebral fracture can be reduced through improvement in the horizontal trabecular connection of vertebral bodies (Fig 7) (20). Through understanding both the benefits and shortcomings of exercise, we can prescribe the proper program for prevention and treatment of osteoporosis and reduction of falls.  To be osteogenic, the exercise stimulus must be loading type, not supportive (21,22). Devising an exercise program for the prevention and treatment of bone loss requires consideration of the subject’s bone density, muscle strength, cognition, coordination, balance and cardiovascular health.  Kyphoplasty and vertebroplasty can significantly decrease pain related to vertebral fracture. Our recent retrospective study showed that Rehabilitation of Osteoporosis Program–Exercise (ROPE) after vertebroplasty significantly decreased incidence of fracture recurrence (P=.001) (Fig. 8). In addition, pharmacotherapy combined with rehabilitation of osteoporosis program is more effective than pharmacotherapy alone (24).
Before prescribing an exercise program for osteoporotic individuals older than 65 years of age, several factors need to be considered: 1) the objective of the exercise program; 2) the biomechanical competence of the spine and musculoskeletal health in general; 3) the status of neuromuscular health; 4) cardiovascular fitness; 5) past history of sports activities and interest; and 6) the patient’s environment (6).
Calcium and vitamin D are basic therapeutic options for osteoporosis prevention and management. Until recently, estrogen was commonly prescribed for postmenopausal syndrome and bone health.  However, the Women’s Health Initiative study concluded that the benefits of HRT do not outweigh the risks of long term treatment (25). At present, some of the benefits of HRT include reduction of hip fractures, colorectal cancer, and reduction of cognitive impairment.  On the other hand, risks include an increased chance of breast cancer, coronary artery disease, stroke, deep venous thrombosis, and cholecystitis. The effect of HRT on cardiovascular disease depends on the age of women. Recent reports indicate that women younger than age 60 who took hormones had a 39% reduction in total mortality as compared to women of a similar age who did not take the drug. Additional pharmacotherapy options include antiresorptive agents such as bisphosphonates in the form of alendronate or risedronate and bone-forming agents such as teriparatide. The choice of pharmacotherapy depends on the patient’s age, bone mineral density and serum biochemical markers of bone.  HRT should not be used for treatment of osteoporosis.
Bone loss and osteoporosis cause an imbalance in musculoskeletal stability.  Increased bone porosity decreases the biomechanical competence of bone.  Trauma to the skeletal structure can vary from gravity alone to the high impact of a moving, energized body part to the floor.  The point of no return from fracture is defined by bone mass and resilience (16).
Prevention of falls and decreasing risk of fracture is important for managing osteoporosis (3).  A significant reduction in back pain and risk of falls and improvement in the level of physical activity have been achieved through the SPEED program (p<0.05).  Subjects who performed the SPEED program decreased their fear of fall and Computerized Dynamic Posturography and gait lab analysis demonstrated reduced risk of falls (Fig 9 and 10), (11).    
In summary, as with pharmacotherapy, rehabilitation management is challenging and innovative. To complement pharmacotherapy, individualized osteogenic exercises and rehabilitative measures need to be provided to the patient.  Loading exercises are preferred to endurance exercises for improvement of bone mass and reduction of bone loss.  Strengthening of axial muscle support can improve mobility in older individuals and decrease kyphosis and risk of vertebral fractures.  Studies have shown that even if exercise does not increase bone mass, it can still be beneficial for reducing vertebral fracture, improving dysequilibrium and decreasing the risk of falls and appendicular fractures.

Address for Correspondence/Yazışma Adresi: Mehrsheed Sinaki, M.D., M.S.,  Professor of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA Phone:  507-284-4904 Fax:  507-284-3431 E-mail: sinaki.mehrsheed@mayo.edu Received/Geliş Tarihi: 31.03.2009 Accepted/Kabul Tarihi: 18.04.2009

References

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